Primary Generalized Glucocorticoid Resistance And Hypersensitivity
January 2011
in “
Hormone Research in Paediatrics
”
TLDR The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.
The document reviews the conditions of Primary Generalized Glucocorticoid Resistance (PGGR) and Primary Generalized Glucocorticoid Hypersensitivity (PGGH), which are caused by mutations or polymorphisms in the human glucocorticoid receptor (hGR) gene. These genetic alterations affect the body's sensitivity to glucocorticoids, leading to various clinical symptoms and influencing biological processes such as stress response, immune function, and metabolism. The review discusses molecular studies used for diagnosis, clinical manifestations, and treatment approaches, highlighting the importance of personalized dosing in glucocorticoid therapy due to interindividual variations in glucocorticoid sensitivity. The document does not provide specific numbers of people involved in studies, as it is a literature review summarizing expert knowledge up to May 2011.
