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    Glossary Glucocorticoid Resistance

    condition where tissues are less responsive to steroid hormones

    Glucocorticoid Resistance, also known as Steroid Resistance, is a condition where the body's tissues are less sensitive or unresponsive to glucocorticoids, which are a type of steroid hormone used to reduce inflammation and regulate immune responses. This can make it difficult to treat conditions like asthma, rheumatoid arthritis, and certain autoimmune diseases, as the usual doses of glucocorticoids become less effective.

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    1. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    2. Primary Generalized Glucocorticoid Resistance and Hypersensitivity Hormone Research in Paediatrics · 2011 · 48 citations
    3. Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance Hormones · 2016 · 15 citations
    4. Generalised Glucocorticoid Resistance touchREVIEWS in Endocrinology · 2008 · 1 citations
    5. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor Springer eBooks · 2016
    6. Generalised Glucocorticoid Resistance US endocrinology · 2008
    7. Glucocorticoid Resistance Syndrome in 2 Patients With Diverse Genotype JCEM Case Reports · 2025
    8. The Glucocorticoid Resistance Syndrome. Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene JCEM case reports · 2023
    9. LBODP010 A Case of Glucocorticoid Resistance Syndrome Journal of the Endocrine Society · 2022
    10. Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes Hormones · 2017 · 15 citations
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