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    Glossary Glucocorticoid Resistance

    condition where tissues are less responsive to steroid hormones

    Glucocorticoid Resistance, also known as Steroid Resistance, is a condition where the body's tissues are less sensitive or unresponsive to glucocorticoids, which are a type of steroid hormone used to reduce inflammation and regulate immune responses. This can make it difficult to treat conditions like asthma, rheumatoid arthritis, and certain autoimmune diseases, as the usual doses of glucocorticoids become less effective.

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    1. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    2. Primary Generalized Glucocorticoid Resistance and Hypersensitivity Hormone Research in Paediatrics · 2011 · 48 citations
    3. Recent advances in the molecular mechanisms causing primary generalized glucocorticoid resistance Hormones · 2016 · 15 citations
    4. Generalised Glucocorticoid Resistance touchREVIEWS in Endocrinology · 2008 · 1 citations
    5. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor Springer eBooks · 2016
    6. Generalised Glucocorticoid Resistance US endocrinology · 2008
    7. Glucocorticoid Resistance Syndrome in 2 Patients With Diverse Genotype JCEM Case Reports · 2025
    8. The Glucocorticoid Resistance Syndrome. Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene JCEM case reports · 2023
    9. LBODP010 A Case of Glucocorticoid Resistance Syndrome Journal of the Endocrine Society · 2022
    10. Novel insights into the molecular mechanisms underlying generalized glucocorticoid resistance and hypersensitivity syndromes Hormones · 2017 · 15 citations
    11. An overview of animal models induced by glucocorticoids Physiology and Pharmacology · 2023
    12. 5α-Reductase Type 1 Deficiency or Inhibition Predisposes to Insulin Resistance, Hepatic Steatosis, and Liver Fibrosis in Rodents Diabetes · 2014 · 93 citations
    13. Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid ˜The œAmerican journal of pathology · 2010 · 19 citations
    14. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis Hormone Molecular Biology and Clinical Investigation · 2014 · 15 citations
    15. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene 2002 · 94 citations
    16. Chrousos syndrome: from molecular pathogenesis to therapeutic management European Journal of Clinical Investigation · 2015 · 47 citations
    17. Metabolic dysfunction in female mice with disruption of 5α-reductase 1 2017 · 11 citations
    18. Management Approaches to Congenital Adrenal Hyperplasia in Adolescents and Adults; Latest Therapeutic Developments InTech eBooks · 2011 · 7 citations
    19. Mucocutaneous Manifestations of Endocrine Disorders John Wiley & Sons, Ltd eBooks · 2013
    20. [Hirsutism and hypertrichosis in adults: investigations and treatment]. PubMed · 2002 · 3 citations
    21. The Polycystic Ovary Syndrome and Acne Springer eBooks · 2014 · 2 citations
    22. Acne-Associated Syndromes Springer eBooks · 2019
    23. Rare Challenges in Diagnosing Cushing’s Syndrome and Primary Aldosteronism: A Case Report of a Female With a Negative Workup Curēus · 2023
    24. Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells Biochemical and Biophysical Research Communications · 2007 · 34 citations
    25. Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide Journal of Investigative Dermatology · 2007 · 2 citations
    26. A Real-World Study of Steroid-Free Monotherapy with Tofacitinib in Severe and Therapy-Recalcitrant Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Cases: A Retrospective Analysis Indian Dermatology Online Journal · 2023
    27. Androgen receptor-mediated gene activation in prostate cancer cells UEF eRepo (University of Eastern Finland) · 2010 · 1 citations
    28. Hormonal treatment of acne vulgaris: an update Clinical, Cosmetic and Investigational Dermatology · 2016 · 46 citations
    29. ANIFROLUMAB IN THE MANAGEMENT OF LUPUS HEADACHES: A CASE REPORT The Journal of Rheumatology · 2025 · 1 citations
    30. Case Report: Alopecia areata in an adolescent after COVID-19 infection Frontiers in Pediatrics · 2026