Chronic Inflammatory Diseases Stimulated by Current Lifestyle: How Diet, Stress Levels, and Medication Prevent Our Body from Recovering

The 2012 document highlights how modern lifestyle factors—diet, stress, and the chronic use of anti-inflammatory medication—disrupt the body's natural inflammation resolution process, known as Resoleomics, leading to chronic inflammation and an increased risk of chronic diseases. The immune system, which is designed for short-term responses, is constantly activated by these stressors, preventing effective inflammation resolution. The review points out that dietary changes since the agricultural and industrial revolutions have led to an imbalance in fatty acids, increased intake of saturated fats and refined carbohydrates, and decreased intake of certain vitamins and antioxidants, all contributing to systemic stress and chronic inflammation. Medications for chronic inflammatory diseases, such as NSAIDs, glucocorticoids, DMARDs, and cytokine blockers, may suppress symptoms but can also interfere with Resoleomics, hindering the body's recovery. The document suggests that adopting an ancestral diet, managing stress, and incorporating physical activity could improve health outcomes by restoring the body's ability to resolve inflammation and return to homeostasis. Further research is called for to develop a questionnaire for early symptoms of chronic low-grade inflammation and to validate the proposed approaches to treatment.