TLDR Strong skin creams work well for long-term scalp inflammation in Rapp-Hodgkin Ectodermal Dysplasia.
The document from 2016 discussed the effectiveness of high-potency topical steroids in treating chronic scalp inflammation in patients with Rapp-Hodgkin Ectodermal Dysplasia (RHS). It presented two cases where patients saw significant improvement in scalp lesions after other treatments had failed. The study drew parallels between RHS and erosive pustular dermatosis of the scalp (EPDS), which also responds to potent topical steroids, and suggested that the inflammation might be due to a reaction to dystrophic hairs. The conclusion was that high-potency topical steroids are a successful treatment for the chronic scalp dermatitis associated with RHS.
33 citations,
February 2012 in “British Journal of Dermatology” Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.
22 citations,
August 2011 in “Journal of the American Academy of Dermatology” Topical tacrolimus can effectively treat erosive pustular dermatosis and related hair loss.
38 citations,
November 2006 in “Pediatric dermatology” Infants with scalp injuries developed a skin condition that improved with steroid creams.
25 citations,
September 2005 in “Journal of the American Academy of Dermatology” Rapp-Hodgkin syndrome, AEC, and EEC are different expressions of the same genetic disorder caused by TP63 gene mutations.
187 citations,
May 1979 in “British Journal of Dermatology” Topical steroids can manage chronic scalp pustules in elderly women.
5 citations,
October 2018 in “Burns” Most patients who had scalp skin removed for burns as children had normal hair growth and were satisfied years later.
4 citations,
July 2015 in “Case Reports in Dermatology” A woman with unexplained hair loss was found to have harmless skin tumors and a scarring hair loss condition, but the tumors didn't cause the hair loss.
