A Variant of the Glucocorticoid Receptor Gene Is Not Associated with Adrenal Androgen Excess in Women with Polycystic Ovary Syndrome

    December 2000 in “ Fertility and Sterility ”
    Melissa Kahsar-Miller, Ricardo Azziz, Eleanor Feingold, Selma F. Witchel
    Image of study
    TLDR The N363S gene variant does not cause higher adrenal androgen levels in women with polycystic ovary syndrome.
    The study investigated the prevalence of the N363S variant of the glucocorticoid receptor gene in 114 women with polycystic ovary syndrome (PCOS) and 92 healthy controls to assess its association with adrenal androgen (AA) excess. It was found that 5.5% of the PCOS patients carried the N363S mutation heterozygously, but there was no significant difference in allele frequency when comparing PCOS patients with and without AA excess to the control group. No subjects were homozygous for the N363S allele. The study concluded that the N363S variant is not common and does not significantly contribute to the genetic predisposition to PCOS or AA excess in women with PCOS.
    Discuss this study in the Community →

    Related Community Posts Join

    5 / 5 results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community NootBro Recommendations… How Do We Feel

      in Research/Science  9 upvotes 9 months ago
      The conversation is about hair loss treatments, specifically a stack including topical Ashwagandha, Copper Peptide, Gotu Kola, Ketoconazole, and PDA. One user found Topical and Sub-Q GHK-CU effective.

      community We Need A Solution For The Inflammatory Response related To AGA

      in Research/Science  16 upvotes 6 months ago
      The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

      community AA and Hirsutism but T levels are normal

      in Female  8 upvotes 4 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

    Similar Research

    5 / 1000+ results