Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

    April 2017 in “ Hormones ”
    Nicolas C. Nicolaides, Evangelia Charmandari
    Studysummary This review discusses the roles of glucocorticoids and glucocorticoid receptors, and it explores potential genetic and non-genetic causes of glucocorticoid resistance or hypersensitivity syndromes, reporting no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. Recent Advances in the Molecular Mechanisms Causing Primary Generalized Glucocorticoid Resistance Hormones · 2016
    2. Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management European Journal of Clinical Investigation · 2015
    3. Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor BMC Endocrine Disorders · 2014
    4. Primary Generalized Glucocorticoid Resistance And Hypersensitivity Hormone Research in Paediatrics · 2011
    5. A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005
    6. Female Pseudohermaphroditism Caused by a Novel Homozygous Missense Mutation of the GR Gene ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2002