Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes
July 2017
in “
Hormones
”
glucocorticoids human glucocorticoid receptor hGR NR3C1 gene Primary Generalized Glucocorticoid Resistance Hypersensitivity Syndromes glucocorticoid signal transduction hGR isoforms genomic glucocorticoid signaling nongenomic glucocorticoid signaling mitochondrial glucocorticoid signaling GR interactome
TLDR Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.
The 2017 review discussed the role and mechanisms of glucocorticoids, hormones crucial for many physiological functions and maintaining homeostasis, and their interaction with the human glucocorticoid receptor (hGR). Genetic defects in the NR3C1 gene, which encodes the hGR, can lead to Primary Generalized Glucocorticoid Resistance or Hypersensitivity Syndromes, conditions characterized by partial impaired tissue sensitivity to glucocorticoids. However, some patients with symptoms of these syndromes do not have mutations in the NR3C1 gene, suggesting other factors may influence glucocorticoid signal transduction. The review also discussed the multiple hGR isoforms and the genomic, nongenomic, and mitochondrial glucocorticoid signaling cascade. The authors speculated that next-generation sequencing technologies would provide a deeper understanding of the GR "interactome".
