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research Novel Insights Into the Molecular Mechanisms Underlying Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes

15 citations , April 2017 in “Hormones”

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

research Generalized Glucocorticoid Resistance

1 citations , January 2008 in “touchREVIEWS in Endocrinology”

Generalized glucocorticoid resistance causes hormone imbalances and varied symptoms due to gene mutations.

research Generalized Glucocorticoid Resistance

January 2008 in “US endocrinology”

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management

47 citations , February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

research Recent Advances in the Molecular Mechanisms Determining Tissue Sensitivity to Glucocorticoids: Novel Mutations, Circadian Rhythm, and Ligand-Induced Repression of the Human Glucocorticoid Receptor

62 citations , August 2014 in “BMC Endocrine Disorders”

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

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community We Need A Solution For The Inflammatory Response related To AGA

in Research/Science 16 upvotes 1 year ago

The conversation is about finding a solution for scalp inflammation related to AGA, with the user expressing frustration that Minoxidil and Finasteride do not address inflammation. The user has researched glucocorticoids and topical NSAIDs for reducing inflammation and seeks advice from specialists.

community M18 Is it smart to start with minox only?

in General 126 upvotes 1 year ago

An 18-year-old is considering starting minoxidil for hair loss due to a receding hairline but is hesitant about using finasteride due to age and lack of health insurance. A suggestion was made to use topical finasteride and minoxidil, along with lifestyle changes like exercise and cold showers.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 9 months ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community Is it sufficient to block scalp DHT topically, or is it also necessary to reduce serum DHT? (My Question is Elaborated Below)

in Research/Science 17 upvotes 10 months ago

Topical finasteride can be as effective as oral finasteride for hair regrowth with fewer systemic side effects, but precise dosing is essential. Combining oral dutasteride with topical finasteride is not recommended due to dutasteride's stronger inhibition.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 1 year ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

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