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Glossary Genetic Studies

involves examining DNA to understand gene influence on traits

Genetic Studies, also known as Genetic Research or Genomic Studies, involve examining DNA to understand how genes influence traits, diseases, and overall health. These studies can identify genetic variations that contribute to conditions like alopecia, helping researchers develop targeted treatments and preventive strategies.

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Research

5 / 1000+ results

research Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes

37 citations , January 2010 in “Human Molecular Genetics”

In this study using mice with specific gene knockouts, both farnesyltransferase and geranylgeranyltransferase-I were found to be essential for the proliferation and survival of skin keratinocytes.

research Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes

3 citations , February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY”

This systematic review and meta-analysis found 30 genetic loci associated with skin ageing phenotypes, noting shared biological pathways in aspects like pigmentation and wrinkling; researchers suggest further studies targeting the same SNP across populations could clarify these associations.

research Clinical and molecular genetic studies in hereditary hair loss

August 2021

This genetic study identified a potential interval for the Marie Unna hypotrichosis gene but found no mutations in the nearby hr gene, suggesting its involvement remains unconfirmed.

Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

research Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency

81 citations , July 2008 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.

research Hormonal regulation in male androgenetic alopecia—Sex hormones and beyond: Evidence from recent genetic studies

15 citations , June 2020 in “Experimental Dermatology”

This review discusses recent genetic findings on hormonal signaling pathways in androgenetic alopecia, reporting no new study results but highlighting the need for further investigation.

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Community Join

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community Creatine and Hair Loss: Are the studies misleading?

74 upvotes 1 month ago

Some users believe creatine may cause hair loss, citing anecdotal evidence and criticizing study flaws. Others argue there's no proven link between creatine and hair loss, suggesting any shedding might be due to other factors or genetic predisposition.

community abusing caffeine boosts DHT levels!

in Research/Science 1 upvotes 1 year ago

Caffeine intake may increase DHT levels, but its impact on hair loss is minimal compared to genetic factors. Excessive caffeine can cause health issues, and its effects on hair loss are not directly applicable to humans based on rat studies.

community Hair Loss Factors in Moms: Analyzing Hormonal Changes, Stress, Genetics, and More

4 upvotes 3 years ago

Hair loss in moms can be caused by hormonal changes, stress, genetics, and nutritional deficiencies. Solutions include hair toppers, Minoxidil, PRP therapy, and a healthy diet with supplements.

community Genetic variations associated with response to Dutasteride. Why is it never mentioned?

in Research/Science 26 upvotes 1 year ago

Genetic variations influence how people respond to dutasteride for hair loss, with some benefiting more from finasteride. Dutasteride is effective for most, but genetic differences may cause it to be less effective for some.

community With studies showing that 0.2mg Finasteride is almost as effective as 5mg at reducing DHT, why is every doctor prescribing 1mg?

252 upvotes 9 months ago

Finasteride is prescribed at 1mg because it is FDA-approved and proven effective, despite evidence that 0.2mg may similarly reduce DHT. The 1mg dose is more effective for hair growth, and lower doses are less available.

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Learn

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learn HMI-115

much-hyped research compound targeting prolactin receptor in scalp

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Vitamin B1

Thinning hair over time? It might not just be genetics: lack of B1 and B2 could be silently working against you. There is no verified human trial showing that B1 or B2 deficiency causes thinning hair or that correcting it regrows hair; a 2019 review concludes the role of micronutrients in hair loss is real but unclear and still needs controlled trials.

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