Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies

June 2020 in “ Experimental Dermatology ”

Stefanie Heilmann-Heimbach, Lara M. Hochfeld, Sabrina Henne, Markus M. Nöthen

androgenetic alopecia sex hormones androgens estrogens androgen receptor AR signaling pathway KLF8 ESR1 RORA PRKCA melatonin parathyroid hormone corticotropin releasing hormone AGA AR CRH

TLDR Hormones and genes affect hair growth and male baldness.

This document summarizes recent genetic studies on hormonal regulation in male androgenetic alopecia (AGA). The studies suggest that sex hormones, such as androgens and estrogens, play a role in regulating hair growth and cycling. The androgen receptor (AR) signaling pathway, as well as genes such as KLF8, ESR1, RORA, and PRKCA, are also implicated in AGA. Melatonin and parathyroid hormone are also discussed as potential regulators of hair growth. Corticotropin releasing hormone is mentioned as a regulator of the stress-response system, which may affect hair growth. Overall, the studies suggest a complex interplay of hormones and genes in the regulation of hair growth and AGA.

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