GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

    November 2017 in “ Nature Communications ”
    Nicola Pirastu, Peter K. Joshi, Paul S. de Vries … James F. Wilson
    Studysummary This genome-wide association study identified 71 genetic loci linked to male pattern baldness, with 30 novel loci, explaining 38% of the risk and suggesting shared pathways with lifespan and cancer traits.
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    Research cited in this study 14

    1. Meta-Analysis Identifies Novel Risk Loci and Yields Systematic Insights into the Biology of Male-Pattern Baldness Nature communications · 2017
    2. Genetic Prediction of Male Pattern Baldness PLoS Genetics · 2017
    3. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    4. Male Pattern Baldness in Relation to Prostate Cancer-Specific Mortality: A Prospective Analysis in the NHANES I Epidemiologic Follow-Up Study American Journal of Epidemiology · 2016
    5. Male Pattern Baldness and Risk of Colorectal Neoplasia British Journal of Cancer · 2016
    6. Prediction of Male-Pattern Baldness from Genotypes European Journal of Human Genetics · 2015
    7. Alopecia and Its Association with Coronary Heart Disease and Cardiovascular Risk Factors: A Meta-Analysis International Journal of Cardiology · 2014
    8. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    9. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    10. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    11. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    12. EDA2R Is Associated With Androgenetic Alopecia Journal of Investigative Dermatology · 2008
    13. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    14. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003