GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

    January 2017
    Nicola Pirastu, Peter K. Joshi, Paul S. de Vries, Marilyn C. Cornelis, Paul McKeigue, NaNa Keum, Nora Franceschini, Marco Colombo, Edward L. Giovannucci, Athina Spiliopoulou, Lude Franke, Kari E. North, Peter Kraft, Alanna C. Morrison, Tõnu Esko, James F. Wilson
    TLDR 71 genetic markers explain 38% of male-pattern baldness risk.
    A genome-wide association study involving over 70,000 men identified 71 loci associated with male pattern baldness (MPB), with 30 being novel, explaining 38% of the risk. This suggested that MPB was less genetically complex compared to other traits. The study highlighted genes and pathways relevant to baldness and found significant pathway-specific genetic correlations with traits like lifespan and cancer, despite only a genome-wide correlation with height. This research expanded the understanding of MPB's genetic architecture and offered insights into shared biological pathways of complex diseases.
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