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GlossaryGenome-Wide Association Study (GWAS)

research method identifying genetic variants linked to specific traits

A Genome-Wide Association Study (GWAS) is a research approach used to identify genetic variations linked to specific diseases or traits by scanning the genomes of many individuals. By comparing the DNA of people with and without a particular condition, researchers can pinpoint genetic markers that may contribute to the risk of developing that condition, providing insights into its biological mechanisms.

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research GWAS for Male-Pattern Baldness Identifies 71 Susceptibility Loci Explaining 38% of the Risk

57 citations, November 2017 in “Nature Communications”

Researchers found 71 genetic regions linked to male pattern baldness, which account for 38% of its genetic risk.

research A Conditional Multi-Trait Sequence GWAS Discovers Pleiotropic Candidate Genes and Variants for Sheep Wool, Skin Wrinkle, and Breech Cover Traits

11 citations, July 2021 in “Genetics selection evolution”

Researchers found genes and genetic variants linked to sheep wool and skin wrinkles.

research MendelVar: Gene Prioritization at GWAS Loci Using Phenotypic Enrichment of Mendelian Disease Genes

2 citations, April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

MendelVar is a tool that helps identify important genes by combining GWAS data with Mendelian disease information.

research GWAS Identifies Three Susceptibility Loci for Trichilemmal Cysts

September 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Three genes linked to the development of trichilemmal cysts were found.

research Multi-Trait Analysis of GWAS: Perceived Youthfulness in the UK Biobank

January 2024 in “Zenodo (CERN European Organization for Nuclear Research)”

The conclusion is that certain traits, including perceived facial aging and BMI, are linked to perceived youthfulness differently in men and women.

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community The theory that explains everything. Community Crowdfund

in Chat 101 upvotes 3 years ago

3aHSD enzyme's role in hair loss and a crowdfund for research. Goal: explore new treatments, study RU58841, and develop natural topical product.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 104 upvotes 3 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.