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GlossaryPolygenic Risk Score

numerical estimate of genetic predisposition based on multiple variants

A Polygenic Risk Score (PRS) is a numerical value that estimates an individual's genetic predisposition to a particular trait or disease, based on the cumulative effect of multiple genetic variants. By analyzing data from genome-wide association studies (GWAS), researchers can calculate a PRS to predict the likelihood of conditions such as alopecia, heart disease, or diabetes, providing valuable insights for personalized medicine and preventive healthcare.

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research Polygenic Risk Score Predicting Susceptibility and Outcome of Benign Prostatic Hyperplasia in the Han Chinese

June 2023 in “Research Square (Research Square)”

A higher genetic risk score increases the chance of getting benign prostatic hyperplasia and affects treatment outcomes in Han Chinese men.

research Evidence for a Polygenic Contribution to Androgenetic Alopecia

26 citations, October 2013 in “British Journal of Dermatology”

Hair loss risk is influenced by multiple genes.

research A Genetically Defined Male Counterpart of Polycystic Ovary Syndrome: Evidence for Ovarian-Independent Pathogenesis

2 citations, May 2021 in “Journal of the Endocrine Society”

Men with high genetic risk for Polycystic Ovary Syndrome (PCOS) have increased chances of obesity, type 2 diabetes, heart disease, and hair loss, showing PCOS risk factors can affect both genders.

research Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome

September 2023 in “The Journal of clinical endocrinology and metabolism”

Genetic risk for PCOS can affect children's growth, metabolism, and development from early life into adulthood.

research Analysis of 72,469 UK Biobank Exomes Links Rare Variants to Male-Pattern Hair Loss

September 2023 in “Nature Communications”

Rare genetic variants in five specific genes are linked to male-pattern hair loss but only account for a small part of the risk.

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community After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?

in Finasteride/Dutasteride 95 upvotes 6 months ago

After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 105 upvotes 3 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Try to find picture of Justin Bieber without a hat in the last two years - challenge impossible

in Chat 164 upvotes 7 months ago

The conversation discusses Justin Bieber's apparent hair loss and the public's reaction to it, with some speculating he's had a hair transplant or is avoiding hair loss medications due to side effects or medical conditions. There's also mention of his past comments on Prince William's balding and the irony of his current situation.

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