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    Glossary Polygenic Risk Score

    numerical estimate of genetic predisposition based on multiple variants

    A Polygenic Risk Score (PRS) is a numerical value that estimates an individual's genetic predisposition to a particular trait or disease, based on the cumulative effect of multiple genetic variants. By analyzing data from genome-wide association studies (GWAS), researchers can calculate a PRS to predict the likelihood of conditions such as alopecia, heart disease, or diabetes, providing valuable insights for personalized medicine and preventive healthcare.

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    1. Polygenic risk score predicting susceptibility and outcome of benign prostatic hyperplasia in the Han Chinese Human Genomics · 2024 · 1 citations
    2. Polygenic risk score predicting susceptibility and outcome of benign prostatic hyperplasia in the Han Chinese Research Square (Research Square) · 2023
    3. Evidence for a polygenic contribution to androgenetic alopecia British Journal of Dermatology · 2013 · 26 citations
    4. Reconsidering the Polycystic Ovary Syndrome (PCOS) Biomedicines · 2022 · 41 citations
    5. Systematic investigation of a potential epidemiological and genetic association between male androgenetic alopecia and COVID‐19 Skin health and disease · 2021 · 2 citations
    6. A Genetically Defined Male Counterpart of Polycystic Ovary Syndrome: Evidence for Ovarian-Independent Pathogenesis Journal of the Endocrine Society · 2021 · 2 citations
    7. Pediatric Features of Genetic Predisposition to Polycystic Ovary Syndrome ˜The œJournal of clinical endocrinology and metabolism · 2023
    8. Dermatological diseases from a genetic perspective Medizinische Genetik · 2023
    9. What Is the Male Polycystic Ovary Syndrome Phenotype? 2021
    10. Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss Nature Communications · 2023
    11. Do Alopecia Areata and Hair Colour Have a Shared Genetic Component? Experimental Dermatology · 2026
    12. Longitudinal Assessment of the Prevalence of Actinic Keratosis and Extensive Risk Factor Evaluation: An Update from the Rotterdam Study Journal of Investigative Dermatology · 2023 · 10 citations
    13. Multi-ancestry tandem repeat association study of hair colour using exome-wide sequencing bioRxiv (Cold Spring Harbor Laboratory) · 2024
    14. Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies Frontiers in Pharmacology · 2026
    15. Etiopathogenesis of Alopecia Areata Hair therapy & transplantation · 2014 · 2 citations
    16. The Genetic Landscape of Androgenetic Alopecia: Current Knowledge and Future Perspectives Biology · 2026
    17. GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk Nature Communications · 2017 · 57 citations
    18. Comparative Evaluation of Oral Baricitinib and Tofacitinib in Alopecia Areata: A Retrospective Cohort Study Based on SALT Scores Turkish Journal of Dermatology · 2025
    19. Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris European Journal of Human Genetics · 2023 · 29 citations
    20. Risk factors for prostate cancer: a case-control study investigating selected key exposures and their interactions with predisposition genes Jurnal Natural (Faculty of Mathematics and Natural Science, Syiah Kuala University) · 2010
    21. Why are men with premature alopecia at higher risk of benign prostatic hyperplasia? And what about prostate cancer? Expert Review of Dermatology · 2012
    22. Early-onset baldness and the risk of aggressive prostate cancer: findings from a case–control study Cancer Causes & Control · 2017 · 4 citations
    23. Polycystic ovary syndrome: Pathophysiology, Symptoms, Risk factors, and Pharmacological treatment Research Journal for Social Affairs · 2024
    24. Alopecia areata: An update Indian Journal of Dermatology, Venereology and Leprology · 2013 · 67 citations
    25. Dissection of genetic variation and evidence for pleiotropy in male pattern baldness Nature Communications · 2018 · 58 citations
    26. Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-analysis Acta dermato-venereologica · 2023 · 10 citations
    27. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations
    28. Bridging psychoneuroimmunology and homeopathy: Modulating the cellular and emotional cascades in refractory alopecia International Journal of Homoeopathic Sciences · 2026
    29. MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives Frontiers in Cell and Developmental Biology · 2026
    30. Trends in Nanotechnology for Practical Applications Elsevier eBooks · 2018 · 9 citations