Polygenic Risk Score Predicting Susceptibility and Outcome of Benign Prostatic Hyperplasia in the Han Chinese

The study investigated the role of Polygenic Risk Score (PRS) in predicting the incidence and treatment outcome of benign prostatic hyperplasia (BPH) in Han Chinese men. The study involved 6,237 male participants with BPH and 17,170 non-BPH controls. The results showed that a higher PRS was associated with a higher risk of BPH, with the risk being higher in the fourth quartile (Q4) than the first quartile (Q1). The Q4 group also had a larger prostate volume and less volume reduction after 5ARI treatment. Additionally, the Q4 group had a higher risk of Transurethral Resection of the Prostate (TURP). The study concluded that a higher PRS was associated with susceptibility to BPH, higher PSA level, larger prostate volume, inferior response of 5ARI, and higher risk of TURP.