Polygenic Risk Score Predicting Susceptibility and Outcome of Benign Prostatic Hyperplasia in the Han Chinese

    June 2023 in “ Research Square (Research Square) ”
    Sheng-Chun Hung, Li-Wen Chang, Tzu‐Hung Hsiao … I-Chien Chen

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that among male Han Chinese, a higher polygenic risk score was linked to increased risk and poorer treatment outcomes for benign prostatic hyperplasia.
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    Research cited in this study 4

    1. Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates General and Comparative Endocrinology · 2020
    2. Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer Journal of The European Academy of Dermatology and Venereology · 2014
    3. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    4. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003