Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates

May 2020 in “ General and Comparative Endocrinology ”

Julie Robitaille, Valerie S. Langlois

steroid-5α-reductase SRD5a 5α-DHT androgen synthesis pseudohermaphrodism SRD5a1 neurosteroid allopregnanolone SRD5a3 N-glycosylation SRD5a mutations inhibitor exposures hair growth DHT androgen glycosylation

TLDR Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The 2020 review by Julie Robitaille and Valerie S. Langlois discussed the role and consequences of steroid-5α-reductase (SRD5a) deficiency and inhibition in vertebrates. SRD5a is crucial for androgen synthesis, and its deficiency can lead to conditions like pseudohermaphrodism. The review highlighted the role of 5α-DHT in the development of male secondary sexual organs, SRD5a1 in the synthesis of the neurosteroid allopregnanolone, and SRD5a3 in N-glycosylation. It also discussed the effects of SRD5a mutations and inhibitor exposures across species, including effects on hair growth, bone mass, muscle strength, and reproductive health. The review concluded that more research is needed to better understand the regulation of SRD5as from fertilization to adulthood.

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research Consequences of Steroid-5α-Reductase Deficiency and Inhibition in Vertebrates

21 citations , May 2020 in “General and Comparative Endocrinology”

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.