TLDR Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.
The study investigated the expression of 5-α reductase 2 (5-AR 2) in benign prostatic hyperplasia (BPH) and its potential resistance to 5-AR 2 inhibitors. Using 42 human prostate tissue samples, the researchers found that 29% of benign prostate samples did not express the 5-AR 2 protein. They identified that the promoter region of 5-AR 2 contains a CpG island that is methylated in 39% of the samples, which strongly correlated with the absence of 5-AR 2 protein expression (P = 0.0025). The study concluded that methylation of the 5-AR 2 promoter might explain the low or absent expression of 5-AR 2 in some adult prostate tissues, potentially impacting the efficacy of BPH therapy.
1054 citations
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December 2018 in “Assay and Drug Development Technologies” Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.
