Reduced Levels of 5-Alpha Reductase 2 in Adult Prostate Tissue and Implications for BPH Therapy

    February 2011 in “ ˜The œProstate/˜The œprostate ”
    Yinong Niu, Rongbin Ge, Libing Hu, Christian Diaz, Zongwei Wang, Chin‐Lee Wu, Aria F. Olumi
    TLDR Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.
    The study investigated the expression of 5-α reductase 2 (5-AR 2) in benign prostatic hyperplasia (BPH) and its potential resistance to 5-AR 2 inhibitors. Using 42 human prostate tissue samples, the researchers found that 29% of benign prostate samples did not express the 5-AR 2 protein. They identified that the promoter region of 5-AR 2 contains a CpG island that is methylated in 39% of the samples, which strongly correlated with the absence of 5-AR 2 protein expression (P = 0.0025). The study concluded that methylation of the 5-AR 2 promoter might explain the low or absent expression of 5-AR 2 in some adult prostate tissues, potentially impacting the efficacy of BPH therapy.
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