Methylation of CpG Islands in Promoter of Type 2 5-Alpha Reductase and Implications of Finasteride Resistance for BPH Therapy

March 2016 in “ European Urology Supplements ”

S. Jin, Daiming Fan, Z. A. Liu … Yunsong Niu

finasteride 5-α reductase 5-AR2 methylation CpG islands DNMT1 benign prostatic hyperplasia BPH Propecia

Studysummary This study identified that methylation of the 5-AR2 gene promoter is linked to reduced expression of 5-AR2 protein, which may explain why some BPH patients are resistant to finasteride treatment.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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community 5ar Type I in the frontal hair follicles - Dutasteride

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community Does everything that reduces DHT block 5ar?

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community A better treatment would be a localized 5ar inhibitor that breaks down when it enters blood or leaves hair follicle

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