Methylated CpG Dinucleotides in 5-Alpha Reductase 2 Gene Might Explain the Finasteride-Resistance in BPE Patients

    July 2020 in “ European urology open science ”
    Yunsong Niu, Zhihong Lin, Daiming Fan, S. Jin, Z. A. Liu
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    TLDR Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.
    The study aimed to determine the precise sites of methylated CpG dinucleotides in the 5-α reductase 2 gene and their correlation with the expression of 5-α reductase 2 protein in benign prostate enlargement (BPE) patients. The researchers found that 10 methylated CpG dinucleotides in the CpG island of the 5-α reductase 2 gene might lead to the silence of the 5-α reductase 2 gene and absent or reduced expression of the 5-α reductase 2 protein. This may partly account for the resistance to finasteride in certain BPE patients.
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