Methylated CpG Dinucleotides in 5-Alpha Reductase 2 Gene Might Explain the Finasteride-Resistance in BPE Patients

    July 2020 in “ European urology open science ”
    Yunsong Niu, Zhihong Lin, Daiming Fan, S. Jin, Z. A. Liu
    Image of study
    TLDR Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.
    The study aimed to determine the precise sites of methylated CpG dinucleotides in the 5-α reductase 2 gene and their correlation with the expression of 5-α reductase 2 protein in benign prostate enlargement (BPE) patients. The researchers found that 10 methylated CpG dinucleotides in the CpG island of the 5-α reductase 2 gene might lead to the silence of the 5-α reductase 2 gene and absent or reduced expression of the 5-α reductase 2 protein. This may partly account for the resistance to finasteride in certain BPE patients.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 8 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Natural Remedies: Polyphenols and Hair Loss

       18 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  105 upvotes 3 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

    Similar Research

    5 / 1000+ results