Methylated CpG Dinucleotides in 5-Alpha Reductase 2 Gene Might Explain the Finasteride-Resistance in BPE Patients

    July 2020 in “ European urology open science ”
    Yunsong Niu, Zhihong Lin, Daiming Fan, S. Jin, Z. A. Liu
    Image of study
    TLDR Methylated gene parts may cause finasteride-resistance in some enlarged prostate patients.
    The study aimed to determine the precise sites of methylated CpG dinucleotides in the 5-α reductase 2 gene and their correlation with the expression of 5-α reductase 2 protein in benign prostate enlargement (BPE) patients. The researchers found that 10 methylated CpG dinucleotides in the CpG island of the 5-α reductase 2 gene might lead to the silence of the 5-α reductase 2 gene and absent or reduced expression of the 5-α reductase 2 protein. This may partly account for the resistance to finasteride in certain BPE patients.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 1 year ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

      community Which compounds in Saw Palmetto are actually beneficial?

      in Research/Science  3 upvotes 9 months ago
      Saw palmetto's fatty acids, particularly lauric and linoleic acids, inhibit enzymes linked to hair loss, while sterols like beta-sitosterol are less effective due to poor absorption. The conversation questions which specific compounds in saw palmetto contribute to its anti-androgenic effects.

      community Dutasteride power compared to finasteride

      in Finasteride/Dutasteride  15 upvotes 2 weeks ago
      Dutasteride is generally considered more effective than finasteride for hair regrowth, with some users experiencing better results, especially at higher doses. However, individual responses vary, and some users report side effects or no response to either treatment.

    Similar Research

    5 / 1000+ results