Studysummary This study found that post-finasteride syndrome patients showed a tissue-specific methylation pattern of the SRD5A2 promoter in cerebrospinal fluid, potentially affecting neuroactive steroid levels and related behavioral symptoms.
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Research cited in this study 26
- Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
- Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin? Endocrine · 2018
- Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
- Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
- Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
- Persistent Sexual Dysfunction with Finasteride 1 mg Taken for Hair Loss Pharmacotherapy · 2016
- An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
- Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome Skin appendage disorders · 2016
- Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
- Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015
- Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
- Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
- Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
- Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
- Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
- Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
- Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation Expert Opinion on Drug Safety · 2012
- Inhibitors of 5α-Reductase-Related Side Effects in Patients Seeking Medical Care for Sexual Dysfunction PubMed · 2012
- Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
- Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
- Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
- Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
- Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009
- Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
- A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
- Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
