Altered Methylation Pattern of the SRD5A2 Gene in the Cerebrospinal Fluid of Post-Finasteride Patients: A Pilot Study

July 2019 in “ Endocrine connections ”

Roberto Cosimo Melcangi, Livio Casarini, Marco Marino, Daniele Santi, Samantha Sperduti, Silvia Giatti, Silvia Diviccaro, M.G. Grimoldi, Donatella Caruso, Guido Cavaletti, Manuela Simoni

finasteride SRD5A2 gene methylation epigenetic modifications Propecia

TLDR Finasteride affects SRD5A2 gene pattern, possibly causing lasting side effects.

This pilot study investigated the methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients. The study found that the methylation pattern of the SRD5A2 gene was altered in post-finasteride patients compared to controls, suggesting that epigenetic modifications may play a role in the persistent adverse effects of finasteride. However, further studies with larger sample sizes are needed to confirm these findings.

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