Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know?

    August 2015 in “ Reviews in Endocrine and Metabolic Disorders ”
    Abdulmaged M. Traish, Roberto Cosimo Melcangi, Marco Bortolato, Luis Miguel García‐Segura, Michael Zitzmann
    TLDR 5α-reductase inhibitors may cause persistent sexual dysfunction and depression, needing more research on long-term effects.
    The document reviewed the adverse effects of 5α-reductase inhibitors, such as finasteride and dutasteride, used for treating benign prostatic hyperplasia and androgenetic alopecia. It highlighted concerns about persistent sexual dysfunction, depression, and other non-sexual side effects in some users. Studies indicated that finasteride might lead to more severe erectile dysfunction and lower testosterone levels compared to tamsulosin. Additionally, there were discussions on the potential nocebo effect contributing to reported sexual side effects. The document emphasized the need for further research to fully understand the long-term impacts and mechanisms behind these adverse effects.
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      community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

      in Research/Science  11 upvotes 11 months ago
      Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

      community 1 month of using fin, so happy

      in Progress Pictures  862 upvotes 1 year ago
      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 1 year ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

      community Another clueless guy fearmongering and spreading misinformation

      in Chat  251 upvotes 1 year ago
      The conversation discusses hair loss treatments, with some users advocating for finasteride and minoxidil, while others express concerns about potential side effects of finasteride. A social media influencer is criticized for promoting scalp massages and minoxidil over finasteride, which some believe is misinformation.

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