Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

    December 2010 in “ The Journal of Sexual Medicine ”
    Abdulmaged M. Traish, John Hassani, André T. Guay … Michael Hansén
    Studysummary This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 29

    1. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    2. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009
    3. 5-Alpha Reductase Inhibitors and Erectile Dysfunction: The Connection The Journal of Sexual Medicine · 2008
    4. The Effect of 5-Reductase Inhibitors on Erectile Function International Journal of Andrology · 2008
    5. The Effect of 5α-Reductase Inhibition With Dutasteride and Finasteride on Bone Mineral Density, Serum Lipoproteins, Hemoglobin, Prostate Specific Antigen, and Sexual Function in Healthy Young Men ˜The œJournal of urology/˜The œjournal of urology · 2008
    6. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    7. Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone International Journal of Andrology · 2007
    8. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    9. Androgenetic Alopecia: Clinical Features, Classification, and Treatments Endocrinology and Metabolism Clinics of North America · 2007
    10. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    11. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    12. Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders Pharmacology, Biochemistry and Behavior · 2006
    13. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    14. Pharmacogenetic Analysis of Human Steroid 5α Reductase Type II: Comparison of Finasteride and Dutasteride Journal of Molecular Endocrinology · 2005
    15. Reversal of Caffeine-Induced Anxiety by Neurosteroid 3-Alpha-Hydroxy-5-Alpha-Pregnane-20-One in Rats Neuropharmacology · 2005
    16. Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences Pharmacology, Biochemistry and Behavior · 2004
    17. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    18. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003
    19. Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride Journal of Neurochemistry · 2002
    20. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    21. The Effects of Transdermal Dihydrotestosterone in the Aging Male: A Prospective, Randomized, Double-Blind Study ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2002
    22. Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat Biochemical Pharmacology · 2001
    23. The Neurobiology of Sexual Function Archives of General Psychiatry · 2000
    24. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    25. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    26. The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1998
    27. The Efficacy of Terazosin, Finasteride, or Both in Benign Prostatic Hyperplasia The New England Journal of Medicine · 1996
    28. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    29. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995

    Related research 6

    1. What Do We Know About 5-Alpha Reductase Inhibitors? Surgical and Cosmetic Dermatology · 2018
    2. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    3. Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride Journal of Investigative Dermatology · 2016
    4. The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice The FASEB Journal · 2013
    5. A Case of Unilateral Idiopathic Gynecomastia Aggravated by Low-Dose Finasteride (1mg/Day, Propecia) Linchuang pifuke zazhi · 2004
    6. Finasteride-Induced Gynecomastia in a 62-Year-Old Man The American Journal of the Medical Sciences · 1995