Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat
October 2001
in “
Biochemical Pharmacology
”
TLDR GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.
The study compared the effectiveness of two drugs, GI198745 and finasteride, in inhibiting rat type 1 and 2 steroid 5α-reductases. GI198745 was found to be more potent and longer-lasting in inhibiting both enzymes, making it a potentially better treatment option for hair loss and other androgen-related disorders. The study also identified time-dependent inhibition as a factor affecting the progress curves and suggested that the drugs' different in vivo activities may be due to their pharmacokinetic parameters and mechanisms of inhibition.
