Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

    June 1993 in “ Biochemistry
    Bernard Faller, David R. Farley, Hanspeter Nick
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    TLDR Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
    This document from 1993 investigates the interaction between finasteride and 5-alpha-reductase, an enzyme involved in the conversion of testosterone to dihydrotestosterone (DHT). The study found that the association rate constant (kon) between finasteride and 5-alpha-reductase was much lower than expected, which has implications for accurately determining the equilibrium dissociation constant (K₁) and evaluating the potency of inhibitors. The study also investigated the stability of the enzyme and the effect of temperature and pH on the interaction.
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      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

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