Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor

    June 1993 in “ Biochemistry ”
    Bernard Faller, David R. Farley, Hanspeter Nick
    Image of study
    TLDR Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
    This document from 1993 investigates the interaction between finasteride and 5-alpha-reductase, an enzyme involved in the conversion of testosterone to dihydrotestosterone (DHT). The study found that the association rate constant (kon) between finasteride and 5-alpha-reductase was much lower than expected, which has implications for accurately determining the equilibrium dissociation constant (K₁) and evaluating the potency of inhibitors. The study also investigated the stability of the enzyme and the effect of temperature and pH on the interaction.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  65 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 7 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Related Research

    3 / 3 results