Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride

    December 2002 in “ Journal of Neurochemistry ”
    Laura Dazzi, Mariangela Serra, Emanuele Seu, Giulia Cherchi, Maria Pisu, Robert H. Purdy, Giovanni Biggio
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    TLDR Progesterone boosts alcohol's effect on brain, finasteride counters it.
    The study found that progesterone enhances the effects of ethanol on mesocortical dopamine neurons in rats, potentially contributing to alcohol addiction. This effect was antagonized by finasteride, a drug commonly used to treat hair loss. The study suggests a potential role for progesterone and finasteride in the regulation of alcohol addiction.
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