Finasteride-Induced Gynecomastia in a 62-Year-Old Man

June 1995 in “ The American Journal of the Medical Sciences ”

Riccardo Volpi, P A Maccarini, S. Boni, Paolo Chiodera, Vittorio Coiro

finasteride gynecomastia DHT androgen estrogen androgen/estrogen ratio Propecia

TLDR Finasteride caused enlarged breast tissue in a 62-year-old man.

This document reports a case of gynecomastia (enlarged breast tissue) in a 62-year-old man who was taking finasteride, a drug used to treat hair loss and prostate enlargement. The authors suggest that the reduction in DHT levels, along with a possible increase in estrogen levels, may have altered the androgen/estrogen ratio and led to the development of gynecomastia. They recommend close clinical follow-up for patients taking finasteride to monitor for potential systemic side effects.

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Research cited in this study

2 / 2 results

research Prolonged Treatment with Finasteride (a 5α-Reductase Inhibitor) Does Not Affect Bone Density and Metabolism

48 citations, November 1992 in “Clinical Endocrinology”

Long-term finasteride use doesn't change bone density or metabolism.

C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

research C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

55 citations, March 1990 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

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6 / 1000+ results

community Guide To Finasteride and Avoiding Side Effects

in Finasteride/Dutasteride 23 upvotes 2 years ago

The conversation provides a guide on using finasteride for hair loss, suggesting to start with a quarter of a 1mg pill daily after ensuring estradiol levels are within a specific range, and potentially increasing the dose if no side effects occur. It also recommends supplements like DIM, Calcium d-glucarate, and Zinc to manage high estradiol levels and side effects from finasteride.

community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 4 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Just had this wild thought come into my head.

in Satire 403 upvotes 9 months ago

The conversation is about the debate over the existence of Post-Finasteride Syndrome (PFS) and its symptoms, with some users skeptical about PFS and others discussing side effects like erectile dysfunction and gynecomastia from hair loss treatments like finasteride. Specific treatments mentioned include finasteride, viagra, and a joke about using a popsicle stick for erectile support.

community Currently crushing 3 (5mg) tablets of fin into my topical min. Anyone do the same? If so how much do you add.

in Treatment 186 upvotes 7 months ago

The conversation discusses using crushed finasteride tablets mixed with topical minoxidil for hair loss treatment. Users share their experiences and opinions on the effectiveness and proper concentration of this method.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 30 upvotes 3 months ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

Related Research

2 / 2 results

research Finasteride-Induced Gynecomastia in a 62-Year-Old Man

15 citations, June 1995 in “The American Journal of the Medical Sciences”

Finasteride caused enlarged breast tissue in a 62-year-old man.

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.