C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency

March 1990 in “ The Journal of Clinical Endocrinology and Metabolism ”

Julianne Imperato-McGinley, Cedric H.L. Shackleton, Susan Orlic, Elizabeth Stoner

finasteride 5α-reductase 5α-dihydrotestosterone DHT testosterone etiocholanolone androsterone male pattern baldness T/DHT ratios Propecia

TLDR Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

This study compares the effects of finasteride on male pseudohermaphrodites with inherited 5α-reductase deficiency and normal males. Finasteride reduces 5α-dihydrotestosterone levels and affects plasma testosterone levels and urinary etiocholanolone/androsterone ratios. The study suggests that finasteride may be effective in treating male pattern baldness. Finasteride inhibits 5α-reductase, leading to decreased DHT levels and increased T/DHT ratios in treated subjects. The study found that finasteride reduces DHT levels and affects the metabolism of specific steroids in subjects. Finasteride may be less effective in treating hair loss in individuals with 5α-reductase deficiency.

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community Pirfenidone - The answer to fibrosis and baldness

in Treatment 19 upvotes 3 years ago

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community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 month ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 month ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Does finasteride/dutasteride reverse aging?

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.