Androgenetic Alopecia: Clinical Features, Classification, and Treatments

    Nina Otberg, Andreas Finner, Jerry Shapiro
    Studysummary This article discusses treatment options for androgenetic alopecia, noting that medical interventions like finasteride and minoxidil can halt and partially reverse hair loss in mild to moderate cases, especially when combined with surgery.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 64

    1. Stem Cells and Their Niches Science · 2006
    2. Effects of Finasteride (1 mg) on Hair Transplant Dermatologic Surgery · 2006
    3. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    4. Hair Transplantation: Current Concepts and Techniques Journal of Investigative Dermatology Symposium Proceedings · 2005
    5. Prevalence of Male and Female Pattern Hair Loss in Maryborough Journal of Investigative Dermatology Symposium Proceedings · 2005
    6. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    7. The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia Cancer Epidemiology, Biomarkers & Prevention · 2005
    8. Association of a Polymorphism in the Ornithine Decarboxylase Gene with Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2005
    9. Evaluation and Treatment of Male and Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2004
    10. Androgen Action on Human Skin – From Basic Research to Clinical Significance Experimental dermatology · 2004
    11. The Latest Developments in Surgical Hair Restoration Facial Plastic Surgery Clinics of North America · 2004
    12. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    13. Family History and Risk of Hair Loss Dermatology · 2004
    14. An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia Dermatology · 2004
    15. Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors British Journal of Dermatology · 2003
    16. The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2003
    17. Male-Pattern Baldness Is Common in Men With X-Linked Recessive Ichthyosis Dermatology · 2003
    18. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    19. The Potential Role of Minoxidil in the Hair Transplantation Setting Dermatologic Surgery · 2002
    20. A Random Study of Asian Male Androgenetic Alopecia in Bangkok, Thailand Dermatologic Surgery · 2002
    21. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    22. Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men Journal of Dermatology · 2002
    23. The Hairless Gene in Androgenetic Alopecia: Results of a Systematic Mutation Screening and a Family-Based Association Approach British Journal of Dermatology · 2002
    24. The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women British Journal of Dermatology · 2001
    25. Sebocytes Are the Key Regulators of Androgen Homeostasis in Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    26. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    27. The Psychology of Hair Loss and Its Implications for Patient Care Clinics in Dermatology · 2001
    28. Early Androgenetic Alopecia as a Marker of Insulin Resistance The Lancet · 2000
    29. Vertex Balding, Plasma Insulin-Like Growth Factor 1, and Insulin-Like Growth Factor Binding Protein 3 Journal of The American Academy of Dermatology · 2000
    30. Management of Androgenetic Alopecia American Journal of Clinical Dermatology · 2000
    31. Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis Dermatology · 2000
    32. An X-Linked Gene Involved in Androgenetic Alopecia: A Lesson to Be Learned from Adrenoleukodystrophy Dermatology · 2000
    33. Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment Journal of The American Academy of Dermatology · 1999
    34. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999
    35. Treatment of Hair Loss The New England Journal of Medicine · 1999
    36. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    37. Absence of Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis Dermatology · 1999
    38. Finasteride Drugs · 1999
    39. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    40. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    41. Hair Regrowth Dermatologic Clinics · 1998
    42. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    43. Balding Hair Follicle Dermal Papilla Cells Contain Higher Levels of Androgen Receptors Than Those From Non-Balding Scalp Journal of Endocrinology · 1998
    44. Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia Journal of Investigative Dermatology · 1997
    45. Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect Journal of Investigative Dermatology · 1997
    46. Androgenetic Alopecia: An Autosomal Dominant Disorder The American Journal of Medicine · 1995
    47. Mechanism of Action of Androgen in Hair Follicles Journal of dermatological science · 1994
    48. Personality Disorders and Psychopathologic Symptoms in Patients With Androgenetic Alopecia Archives of Dermatology · 1994
    49. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993
    50. Minoxidil Specifically Decreases the Expression of Lysine Hydroxylase in Cultured Human Skin Fibroblasts Biochemical Journal · 1992
    51. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    52. Natural Progression of Male Pattern Baldness in Young Men Clinical and Experimental Dermatology · 1991
    53. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    54. Relationship Between Contact Time of Applied Dose and Percutaneous Absorption of Minoxidil From a Topical Solution Journal of Pharmaceutical Sciences · 1990
    55. Five-Year Follow-Up of Men with Androgenetic Alopecia Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1990
    56. Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture Journal of Investigative Dermatology · 1989
    57. Topical Minoxidil Used Before and After Hair Transplantation The Journal of dermatologic surgery and oncology · 1989
    58. The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness Clinics in Dermatology · 1988
    59. Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment Journal of The American Academy of Dermatology · 1987
    60. Long-Term Follow-Up of Men with Male Pattern Baldness Treated with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    61. The Inheritance Of Common Baldness: To Be Or Not To Be? Journal of the American Academy of Dermatology · 1984
    62. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984
    63. Direct Effects of Minoxidil on Epidermal Cells in Culture Journal of Investigative Dermatology · 1984
    64. Giant Cells in Male Pattern Alopecia: A Histologic Marker and Pathogenetic Clue Journal of Cutaneous Pathology · 1979

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    8. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
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