The Hair Loss Encyclopedia

Direct Effects of Minoxidil on Epidermal Cells in Culture

January 1984 in “ Journal of Investigative Dermatology ”

Rhonna L. Cohen, Mário Aquino Alves, Virginia C. Weiss, Dennis P. West, Donald A. Chambers

minoxidil epidermal cells DNA synthesis cell division hair growth epithelial cells epidermal homeostasis Rogaine

Image of study

TLDR Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

The study investigated the direct effects of minoxidil on epidermal cells in culture. The results showed that minoxidil stimulated DNA synthesis and cell division in these cells, suggesting that it may have a direct effect on hair growth. The drug also had direct effects on the proliferation and morphology of epithelial cells. The study suggests that minoxidil may be a useful probe to examine regulatory mechanisms of epidermal homeostasis.

View this study on jidonline.org →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

Pharmacology and Pharmacokinetics of Minoxidil

research Pharmacology and Pharmacokinetics of Minoxidil

57 citations, January 1980 in “Journal of Cardiovascular Pharmacology”

Minoxidil treats high blood pressure and side effects can be managed.

Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

86 citations, September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

Related Community Posts Join

6 / 1000+ results

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 1 month ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Vitamin C and hair growth PH levels

in Product 34 upvotes 2 years ago

The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

community Alright boys, who’s willing to burn their scalp for science?

in Research/Science 765 upvotes 1 year ago

Researching the effects of scalp trauma on hair growth, with some users suggesting experimenting with a soldering iron or derma pen, and others bringing up studies that suggest this may be an effective treatment.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 month ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Clearing the air on how non-surgical treatments really work

18 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

Related Research

7 / 7 results

How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil?

research How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil?

8 citations, April 2020 in “Journal of The American Academy of Dermatology”

Oral minoxidil is a reasonably safe alternative for patients allergic to the topical form.

Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata

research Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata

4 citations, January 2017 in “Indian Dermatology Online Journal”

A child used a hair growth lotion for hair loss, but it caused excessive hair growth on his face and neck instead.

Infantile Generalized Hypertrichosis Caused by Topical Minoxidil

research Infantile Generalized Hypertrichosis Caused by Topical Minoxidil

10 citations, February 2016 in “Anais Brasileiros de Dermatologia”

Topical minoxidil can cause excessive hair growth in children, so use it carefully.

research Long-Pulsed Nd:YAG Laser in the Treatment of Facial Hypertrichosis During Topical Minoxidil Therapy

5 citations, March 2013 in “Journal of cosmetic and laser therapy”

Laser treatment successfully removed unwanted facial hair caused by minoxidil.

Generalized Hypertrichosis After Treatment With Topical Minoxidil

research Generalized Hypertrichosis After Treatment With Topical Minoxidil

20 citations, March 1994 in “Clinical and Experimental Dermatology”

Too much topical minoxidil can cause excessive hair growth, but stopping treatment reverses it.

Direct Effects of Minoxidil on Epidermal Cells in Culture

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations, January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Hypertrichosis Due to Minoxidil

73 citations, November 1979 in “British Journal of Dermatology”

Minoxidil can cause excessive hair growth.