The Hair Loss Encyclopedia

Direct Effects of Minoxidil on Epidermal Cells in Culture

January 1984 in “ Journal of Investigative Dermatology ”

Rhonna L. Cohen, Mário Aquino Alves, Virginia C. Weiss, Dennis P. West, Donald A. Chambers

minoxidil epidermal cells DNA synthesis cell division hair growth epithelial cells epidermal homeostasis Rogaine

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TLDR Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

The study investigated the direct effects of minoxidil on epidermal cells in culture. The results showed that minoxidil stimulated DNA synthesis and cell division in these cells, suggesting that it may have a direct effect on hair growth. The drug also had direct effects on the proliferation and morphology of epithelial cells. The study suggests that minoxidil may be a useful probe to examine regulatory mechanisms of epidermal homeostasis.

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Research cited in this study

2 / 2 results

Pharmacology and Pharmacokinetics of Minoxidil

research Pharmacology and Pharmacokinetics of Minoxidil

57 citations, January 1980 in “Journal of Cardiovascular Pharmacology”

Minoxidil treats high blood pressure and side effects can be managed.

Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

86 citations, September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

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Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

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There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

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18 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

Related Research

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How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil?

research How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil?

8 citations, April 2020 in “Journal of The American Academy of Dermatology”

Oral minoxidil is a reasonably safe alternative for patients allergic to the topical form.

Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata

research Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata

4 citations, January 2017 in “Indian Dermatology Online Journal”

A child used a hair growth lotion for hair loss, but it caused excessive hair growth on his face and neck instead.

Infantile Generalized Hypertrichosis Caused by Topical Minoxidil

research Infantile Generalized Hypertrichosis Caused by Topical Minoxidil

10 citations, February 2016 in “Anais Brasileiros de Dermatologia”

Topical minoxidil can cause excessive hair growth in children, so use it carefully.

research Long-Pulsed Nd:YAG Laser in the Treatment of Facial Hypertrichosis During Topical Minoxidil Therapy

5 citations, March 2013 in “Journal of cosmetic and laser therapy”

Laser treatment successfully removed unwanted facial hair caused by minoxidil.

Generalized Hypertrichosis After Treatment With Topical Minoxidil

research Generalized Hypertrichosis After Treatment With Topical Minoxidil

20 citations, March 1994 in “Clinical and Experimental Dermatology”

Too much topical minoxidil can cause excessive hair growth, but stopping treatment reverses it.

Direct Effects of Minoxidil on Epidermal Cells in Culture

research Direct Effects of Minoxidil on Epidermal Cells in Culture

63 citations, January 1984 in “Journal of Investigative Dermatology”

Minoxidil promotes hair growth by increasing cell division and DNA synthesis.

research Hypertrichosis Due to Minoxidil

73 citations, November 1979 in “British Journal of Dermatology”

Minoxidil can cause excessive hair growth.