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GlossarySkin Cells (Epidermal Cells)

cells forming the outermost layer of skin, providing protection

Skin cells, also known as epidermal cells, are the primary cells that make up the outermost layer of the skin, called the epidermis. These cells play a crucial role in providing a protective barrier against environmental damage, pathogens, and water loss. They include various types such as keratinocytes, which produce the protein keratin, melanocytes, which produce the pigment melanin, and Langerhans cells, which are involved in immune responses.

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learn Low Level Laser Therapy

laser therapy for anti-inflammatory and likely insignificant hair regrowth effects

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research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations, February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties

143 citations, May 2017 in “Nature cell biology”

Wounded skin cells can revert to stem cells and help heal.

research Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells

105 citations, October 2017 in “Stem cells”

Wnt signaling is crucial for skin development and hair growth.

research Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration

83 citations, January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells

83 citations, May 2013 in “International Journal of Molecular Sciences”

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

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community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 206 upvotes 1 month ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community Clearing the air on how non-surgical treatments really work

18 upvotes 5 years ago

Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 673 upvotes 3 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 828 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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