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GlossaryInterfollicular Stem Cells

cells in skin between hair follicles aiding epidermis repair

Interfollicular stem cells are a type of stem cell found in the skin, specifically in the areas between hair follicles. These cells play a crucial role in the regeneration and repair of the skin's outer layer, the epidermis, by continuously producing new skin cells to replace those that are shed or damaged.

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research Characterization of Interfollicular Stem Cells and Early TA Cells During the Transition From Infant to Child Skin

October 2021 in “Journal of Investigative Dermatology”

The study concludes that as skin matures from infancy to childhood, there are major changes in cell differentiation, stemness, and growth, leading to a stronger skin barrier in older children.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice Following Topical Application of Fluocinolone Acetonide

2 citations, November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Toxicological Responses in Keratinocyte Interfollicular Stem Cells

April 2018

Toxins can disrupt skin stem cell balance, causing skin overgrowth or ulceration.

research Lgr6+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors

7 citations, November 2016 in “Oncotarget”

UV exposure reduces Lgr6+ stem cells in mouse skin and they don't significantly contribute to skin cancer development.

research Keratinocyte Stem Cells: Role in Aging

1 citations, March 2022 in “IntechOpen eBooks”

Aging reduces skin stem cell function, leading to changes like hair loss and slower wound healing.

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community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years.

in Treatment 25 upvotes 10 months ago

John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalp DHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.

community does lowering your prolactin levels regrow hair?

in Research/Science 10 upvotes 2 years ago

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

community Been on dut 0.5mg daily for 12 months. I am cooked.

in Progress Pictures 10 upvotes 5 months ago

A user took finasteride for six months, then switched to dutasteride for a year, increasing the dosage over time, but hair shedding worsened. Replies suggest the issue is male pattern baldness and DHT-related.

community HMI-115: What We Know So Far. HMI-115 (also known as BAY1158061) is a new pharmaceutical drug developed by a biopharmaceutical company called Bioinvent and licensed by Bayer

in Research/Science 51 upvotes 7 months ago

HMI-115 is a new drug developed by Bioinvent and licensed by Bayer, with mixed opinions on its potential effectiveness. Some users are skeptical and prefer proven treatments like Minoxidil, finasteride, and RU58841.

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