Toxicological Responses in Keratinocyte Interfollicular Stem Cells

April 2018

Rambon Shamilov, Brian J. Aneskievich

keratinocyte stem cells inorganic arsenic aryl hydrocarbons dioxin bacterially derived toxins hyperplasia hypoplasia epidermis skin ulceration

Studysummary This chapter examines how toxins such as inorganic arsenic, dioxin, and bacterial toxins can disrupt the balance of keratinocyte stem cell regeneration and differentiation, affecting skin barrier maintenance.

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research Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis

118 citations , January 2016 in “Current Topics in Developmental Biology”

This essay discusses the establishment, maintenance, and role of skin stem cells in tissue homeostasis, wound repair, and their relation to skin cancer, without reporting new experimental findings.

research Epidermal Cells Expressing Putative Cell Markers in Nonglabrous Skin Near the Distal End of the Arrector Pili Muscle

5 citations , January 2016 in “Stem Cells International”

This study found that epidermal stem cells in nonglabrous skin are connected to the distal end of the arrector pili muscle, which may play a role in epidermal renewal and wound healing.

research Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications

232 citations , October 2015 in “International journal of molecular sciences”

This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.

research Lineage Analysis of Epidermal Stem Cells

57 citations , January 2014 in “Cold Spring Harbor Perspectives in Medicine”

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

research Innate Immunity and the Regulation and Mobilization of Keratinocyte Stem Cells: Are the Old Players Playing a New Game?

11 citations , July 2012 in “Experimental dermatology”

This article discusses the expression and potential new roles of innate immunity genes in CD49f(+) /CD34(+) hair follicle stem cells, but reports no new experimental results.

research 25 Years of Epidermal Stem Cell Research

55 citations , March 2012 in “Journal of Investigative Dermatology”

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

86 citations , August 2011 in “Toxicological sciences”

In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.

research Ferreting Out Stem Cells From Their Niches

80 citations , May 2011 in “Nature Cell Biology”

This review discusses the progress in identifying stem cells responsible for tissue regeneration and highlights technological advances in tracking their behavior, but reports no new clinical results.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

This review discusses the reuse of molecular mechanisms involved in embryonic skin development for maintaining adult epidermal homeostasis and reports no new results.

research Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?

153 citations , October 2007 in “Cell Stem Cell”

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

research Epidermal and Hair Follicle Progenitor Cells Express Melanoma-Associated Chondroitin Sulfate Proteoglycan Core Protein

51 citations , February 2004 in “Journal of Investigative Dermatology”

MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

TCDD changes skin gene expression and may harm skin health.