Toxicological Responses in Keratinocyte Interfollicular Stem Cells

April 2018

Rambon Shamilov, Brian J. Aneskievich

keratinocyte stem cells inorganic arsenic aryl hydrocarbons dioxin bacterially derived toxins hyperplasia hypoplasia epidermis skin ulceration

TLDR Toxins can disrupt skin stem cell balance, causing skin overgrowth or ulceration.

The document discusses how the skin's barrier function is maintained by the regeneration and differentiation of epidermal keratinocyte stem cells. It highlights the exposure of these cells to various toxins, including inorganic arsenic, aryl hydrocarbons like dioxin, and bacterially derived toxins. The study examines the effects of these toxins on keratinocyte stem cells and how they can disrupt the balance between cell division and differentiation. This disruption can lead to skin conditions such as hyperplasia, which is an overgrowth of the epidermis, or hypoplasia, which results in skin ulceration. The document emphasizes the importance of understanding the mechanisms behind these toxicological responses to maintain healthy skin barrier function.

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