25 Years of Epidermal Stem Cell Research

    March 2012 in “ Journal of Investigative Dermatology ”
    Ruby Ghadially
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    TLDR Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
    The document summarizes the advancements in epidermal stem cell research over the past 25 years, noting an increase in related literature and the evolution of the field from basic studies to more advanced science. Key developments include the identification of holoclones as stem cells and paraclones as transit-amplifying cells, the location of hair follicle stem cells in the bulge, and the use of ß1-integrins as a marker for high proliferative potential. Challenges remain in accurately identifying stem cells due to the limitations of colony-forming efficiency tests. The document also discusses the role of Notch signaling in keratinocyte differentiation, the potential multipotency of interfollicular stem cells, and the importance of in vivo repopulation assays. It highlights the contribution of bone marrow-derived cells to epidermal regeneration, the role of p63 in epithelial stratification, and the mechanisms of stem cell division. The potential of iPS cells derived from keratinocytes for regenerative therapy is mentioned, along with the need for better assays to characterize epidermal stem cells. The document concludes with the significance of epidermal stem cells in clinical therapy and the promise of improved patient treatment through continued research.
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