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GlossaryHair Follicle Bulge (bulge)

specific region housing stem cells for hair growth

The hair follicle bulge is a specific region located in the outer root sheath of the hair follicle. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration, as well as for repairing the skin after injury. This area is essential for the cyclical nature of hair growth and plays a significant role in conditions like alopecia.

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The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

research The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

47 citations, September 2008 in “British Journal of Dermatology”

Ludwig pattern hair loss in women results from varying sensitivity in hair follicles, causing fewer visible hairs.

research Theoretical Considerations in Laser Hair Removal

150 citations, April 1999 in “Dermatologic Clinics”

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

research Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

43 citations, February 2008 in “Journal of cutaneous pathology”

Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.

research Watching Hair Grow: Intravital Two-Photon Imaging of Hair Follicle Regeneration in Transgenic Mice

August 2012 in “Nature Cell Biology”

Hair grows when stem cell offspring in the follicle base proliferate, influenced by the dermal papilla.

research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations, June 2012 in “Nature Immunology”

Hair follicles help attract immune cells to the skin during stress.

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Community Join

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community M32, almost 3 moths, fin oral 1,25g/daily + min 2xday + keto 2% shapoo 1/week microneedling once a week

in Progress Pictures 31 upvotes 1 year ago

A 32-year-old man has been treating his hair loss with daily oral finasteride (1.25g), twice-daily topical minoxidil, weekly ketoconazole 2% shampoo, and weekly microneedling for almost three months, with no side effects from finasteride. He started with a Hamilton Norwood scale rating of 5 and has seen improvement without experiencing pain by using a 0.8mm needle length for microneedling.

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

in Research/Science 279 upvotes 5 days ago

Researchers at the University of Virginia discovered a new group of stem cells in hair follicles that could potentially restore hair growth. The findings suggest that activating these stem cells might offer a new way to combat hair loss, though practical treatments are still years away.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 5 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Hair theory Scar tissue and Verteporfin

in Chat 24 upvotes 8 months ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community Micro needling 25 days progress. I’ve been on fin and min for 6 months but micro needling has done SO much more to actually restore my hairline

in Progress Pictures 569 upvotes 11 months ago

A user shared a 25-day progress picture showing significant hairline restoration attributed to microneedling, in addition to using minoxidil and finasteride for 6 months. Other users discussed needle length, frequency, and whether the effects of microneedling are permanent.

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