Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

April 2010 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Tetsuro Kobayashi, Tadaaki Iwasaki, Masayuki Amagai, Manabu Ohyama

hair follicles stem cell candidates bulge cells label-retaining cells LRCs biomarkers CD200 DIO2 keratinocytes proliferative capacity pilosebaceous structures in vitro in vivo stem cells

TLDR Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.

The study identified and characterized stem cell candidates in canine hair follicles, finding that these cells shared many features with human bulge cells, including the location of label-retaining cells (LRCs) and the expression of biomarkers like CD200 and DIO2. Canine bulge cell-enriched keratinocytes demonstrated high proliferative capacity in vitro and could regenerate pilosebaceous structures in vivo. The findings suggested that canine bulge cells could serve as a valuable model for studying human hair follicle biology and related disorders, despite the small sample size (n=3 to n=9) indicating preliminary findings that need further validation.

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