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GlossaryLabel-Retaining Cells (LRCs)

cells that divide infrequently and retain DNA labels

Label-Retaining Cells (LRCs) are a type of cell that retains a DNA label over an extended period, indicating they divide infrequently. This characteristic is often used to identify stem cells or progenitor cells in tissues, including hair follicles, as these cells typically divide less frequently than other cell types, allowing them to maintain tissue homeostasis and regeneration.

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research Epithelial Stem Cells: Turning Over New Leaves

508 citations, February 2007 in “Cell”

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

36 citations, April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment

25 citations, August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

research Defining the Localization and Molecular Characteristics of Minor Salivary Gland Label-Retaining Cells

18 citations, April 2014 in “Stem cells”

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.

research Context-Dependent Effect of sPLA2-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

13 citations, September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

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