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GlossaryLabel-Retaining Cells (LRCs)

cells that divide infrequently and retain DNA labels

Label-Retaining Cells (LRCs) are a type of cell that retains a DNA label over an extended period, indicating they divide infrequently. This characteristic is often used to identify stem cells or progenitor cells in tissues, including hair follicles, as these cells typically divide less frequently than other cell types, allowing them to maintain tissue homeostasis and regeneration.

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research Canine Follicle Stem Cell Candidates Reside in the Bulge and Share Characteristic Features with Human Bulge Cells

36 citations , April 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.

research Impact of mTORC1 Inhibition on Keratinocyte Proliferation During Skin Tumor Promotion in Wild-Type and BK5.AktWT Mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

Targeted Elimination of Follicular Label-Retaining Cells by Photo-Induced Cell Killing Caused a Defect in Follicular Renewal in Mice

research Targeted Elimination of Follicular Label-Retaining Cells by Photo-Induced Cell Killing Caused a Defect in Follicular Renewal in Mice

8 citations , September 2002 in “Genes to Cells”

Killing specific cells in hair follicles can lead to hair growth problems in mice.

research The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but Not for Maintenance of the Epidermal Stem Cell Compartment

25 citations , March 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin D Receptor is needed for hair growth in mice but not for skin stem cell maintenance.

research Context-Dependent Effect of sPLA2-IIA Induced Proliferation on Murine Hair Follicle Stem Cells and Human Epithelial Cancer

13 citations , September 2019 in “EBioMedicine”

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

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