Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

December 2011 in “ American Journal Of Pathology ”

Yue Zhou, Xuan Jiang, Pengyu Gu, Weiqian Chen, Xuesi Zeng, Xiang Gao

Gsdma3 mutation bulge stem cells alopecia skin inflammation hyperkeratosis catagen delay tumor necrosis factor-α immune cells immune privilege stem cell destruction cyclosporine A primary cicatricial alopecias lichen planopilaris TNF-α CsA

Studysummary This study found that immune-mediated destruction of bulge stem cells is a key factor in the alopecia observed in AE mice, suggesting it as a model for studying primary cicatricial alopecias, particularly lichen planopilaris.

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