Hair Follicle Stem Cells in the Pathogenesis of the Scarring Process in Cutaneous Lupus Erythematosus

January 2009 in “ Autoimmunity Reviews ”

Khitam Al‐Refu, Mark Goodfield

cutaneous lupus erythematosus chronic cutaneous lupus erythematosus CCLE inflammation bulge area hair follicles stem cells cytokeratin 15 CK15 permanent follicle loss scarring cicatricial alopecia inflammatory cell infiltrate CLE scarring alopecia

TLDR Damage to hair follicle stem cells causes permanent hair loss and scarring in cutaneous lupus erythematosus.

The document discussed the role of hair follicle stem cells in the scarring process of cutaneous lupus erythematosus (CLE), particularly chronic CLE (CCLE), which heals with scarring. The inflammation in CCLE often involved the bulge area of hair follicles, where stem cells reside, suggesting that damage to these stem cells might lead to permanent follicle loss. The study highlighted that the expression of the stem cell marker cytokeratin 15 (CK15) diminished in affected areas, indicating potential stem cell damage or differentiation. The involvement of stem cells in primary cicatricial alopecia and CLE was secondary to the surrounding inflammatory process. Further research was recommended to better understand follicular pathology and cell kinetics in this context.

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