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GlossaryKeratin 15 (CK15)

protein crucial for hair follicle stem cell regulation

Keratin 15 (K15) is a type of protein found in the hair follicles and skin, playing a crucial role in the structural integrity and function of these tissues. It is particularly important for the maintenance and regeneration of hair, as it is involved in the regulation of stem cells within the hair follicle, which are essential for hair growth and repair.

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research Cytokeratin 15 Expression in Central, Centrifugal, Cicatricial Alopecia: New Observations in Normal and Diseased Hair Follicles

14 citations, January 2011 in “Journal of Cutaneous Pathology”

CK15 is not a reliable marker for stem cells in damaged hair follicles from patients with CCCA.

research Stem Cell Markers (Cytokeratin 15, CD34, and Nestin) in Primary Scarring and Nonscarring Alopecia

54 citations, January 2009 in “British Journal of Dermatology”

Scarring alopecia affects different hair follicle stem cells than nonscarring alopecia, and the infundibular region could be a new treatment target.

research Hair Follicle Stem Cells in the Pathogenesis of the Scarring Process in Cutaneous Lupus Erythematosus

31 citations, January 2009 in “Autoimmunity Reviews”

Damage to hair follicle stem cells causes permanent hair loss and scarring in cutaneous lupus erythematosus.

research Differential Expression of Stem Cell Markers in Human Follicular Bulge and Interfollicular Epidermal Compartments

28 citations, March 2010 in “Histochemistry and Cell Biology”

Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.

Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

research Human Epithelial Stem Cell Survival Within Their Niche Requires Tonic Cannabinoid Receptor 1 Signaling—Lessons From the Hair Follicle

14 citations, February 2021 in “Experimental Dermatology”

Cannabinoid receptor-1 signaling is essential for the survival and growth of human hair follicle stem cells.

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