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GlossaryBulge Area

specific region in hair follicle housing stem cells

The bulge area is a specific region located in the outer root sheath of a hair follicle. It serves as a reservoir for stem cells that are crucial for hair growth and regeneration. These stem cells can also contribute to the repair of the skin and other tissues, making the bulge area essential for both hair follicle cycling and wound healing.

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Research

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research The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia

February 2024 in “International Journal of Molecular Sciences”

Hair loss in Androgenetic Alopecia is caused by genetics, aging, and lifestyle, leading to hair follicle shrinkage and related health risks.

research Hair Biology and Hair Loss Disorders: An Update and New Concepts

December 2011

Recent discoveries have improved our understanding of hair loss, but challenges in treatment and knowledge among specialists still exist.

research Biology of Human Hair Growth and Common Baldness

January 1998 in “KAGAKU TO SEIBUTSU”

The document suggests that male hormones likely affect hair growth and baldness, and future treatments might involve stem cells and androgen-independent cells.

research The Hair Follicle: Functions, Self-Renewal, and Alopecic Disorders

28 citations , March 2016 in “Toxicologic pathology”

Dogs could be good models for studying human hair growth and hair loss.

Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

research Isoproterenol Directs Hair Follicle-Associated Pluripotent (HAP) Stem Cells to Differentiate In Vitro to Cardiac Muscle Cells Which Can Be Induced to Form Beating Heart-Muscle Tissue Sheets

29 citations , March 2016 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

Isoproterenol helps hair follicle stem cells turn into beating heart muscle cells.

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Community Join

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community Do you keep gains if you stop microneedling?

in Microneedling 15 upvotes 7 months ago

Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

community A Theory on Why Microneedling Works

170 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 52 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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