The Hair Follicle Bulge: A Niche for Adult Stem Cells

    July 2011 in “ Microscopy and Microanalysis ”
    H. Amalia Pasolli
    Image of study
    TLDR The hair follicle bulge is an important area for adult stem cells involved in hair growth and repair, with potential for medical use needing more research.
    The 2011 document highlights the hair follicle bulge as a critical niche for adult stem cells in mice, emphasizing its role in hair follicle growth and regeneration. It details the identification of label-retaining cells (LRCs) in the bulge, the use of fluorescence-activated cell sorting (FACS) to isolate bulge cells, and the confirmation of their stem cell functionality through grafting and lineage tracing experiments. The study also found that outer root sheath (ORS) cells are involved in the formation of a new bulge and hair germ, with the K6+ layer playing a role in anchoring the hair shaft and maintaining stem cell quiescence. The document concludes that while the use of hair follicle stem cells for medical applications holds promise, further research is necessary to fully understand their regulation and potential.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community Does anyone here use everything except Fin

      in Minoxidil  23 upvotes 1 year ago
      The conversation is about hair loss treatments, specifically Minoxidil (Min) and Finasteride (Fin). The original poster is considering using Min and other treatments but is hesitant about Fin, while the responses vary, with some advocating for early use of Fin and others warning about potential side effects.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Clearing the air on how non-surgical treatments really work

       18 upvotes 5 years ago
      Treatments for hair loss, including finasteride, dutasteride, minoxidil, ketoconazole, microneedling, and low level laser light therapy, which aim to reduce DHT production, increase cell absorption and blood flow, and stimulate epidermal stem cells. It also stresses the importance of patience when using these treatments.

      community RU58841 alone vs. with Fin / Dut

      in Finasteride/Dutasteride  11 upvotes 1 year ago
      RU58841 combined with finasteride or dutasteride is more effective than RU58841 alone for hair loss. Users suggest combining these with minoxidil and microneedling for better results.

    Related Research

    1 / 1 results