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GlossaryOuter Root Sheath Keratinocytes (ORS cells)

specialized cells in the hair follicle's outer layer

Outer Root Sheath Keratinocytes are specialized cells found in the outer layer of the hair follicle. These cells play a crucial role in the growth and regeneration of hair, as they provide structural support and contribute to the formation of the hair shaft. For professionals, it's important to note that these keratinocytes are involved in the hair cycle's anagen (growth) phase and can be a focus in studies related to hair loss and treatments for conditions like alopecia.

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research Decorin Promotes Proliferation and Migration of ORS Keratinocytes and Maintains Hair Anagen in Mice

10 citations, August 2018 in “Experimental Dermatology”

Decorin helps hair cells grow and move, and keeps hair growth phase going in mice.

research Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro

51 citations, February 2009 in “Journal of dermatological science”

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

research Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

43 citations, January 2016 in “Cellular physiology and biochemistry”

Epidermal Growth Factor helps hair follicle cells grow and move by activating a specific cell signaling pathway.

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

23 citations, June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles

22 citations, March 2017 in “Scientific reports”

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

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community Verteporfin and Microneedling

in Treatments 6 months ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community What supplements or extra dtuff do you guys do for your hair?

in Product 2 upvotes 3 months ago

OP uses multivitamins, collagen, biotin, keratin, omega-3, satin bonnet, dandruff shampoo, oil moisturizer, and sun exposure for hair care. Users suggest adding antioxidants, probiotics, pumpkin seed oil, vitamin D, iron, and dermastamping.

community [27/m] Just a quick entry on my 1 Month experience with Fin/Redensyl/Dermarolling

in Treatment 6 upvotes 2 years ago

NathanHsn shares 1-month experience using Finasteride, Redensyl, and dermarolling for hair loss, noticing small baby hairs and no major side effects. PonyBoyBleach relates, also using Finasteride and dermarolling, and is interested in progress updates.