Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling

    January 2016 in “ Cellular physiology and biochemistry ”
    Haihua Zhang, Weixiao Nan, Shiyong Wang … Guangyu Li
    Studysummary This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.
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    Research cited in this study 12

    1. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    2. KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin Development · 2009
    3. Akt2 and SGK3 Are Both Determinants of Postnatal Hair Follicle Development The FASEB Journal · 2009
    4. Keratinization of Outer Root Sheath Cells Is Prevented by Contact with Inner Root Sheath of Rat Hair Follicles Archives of Dermatological Research · 2008
    5. Survivin in the Human Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    6. The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis American Journal of Pathology · 2006
    7. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    8. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    9. Hair Growth Induction: Roles of Growth Factors Annals of the New York Academy of Sciences · 1991
    10. Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro Archives of Dermatological Research · 1987
    11. Epidermal Growth Factor And Fibroblast Growth Factor Accelerate Proliferation Of Human Hair Bulb Papilla Cells And Root Sheath Fibroblasts Cultured In Vitro British Journal of Dermatology · 1987
    12. Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle Journal of Investigative Dermatology · 1984

    Related research 3

    1. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    2. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    3. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981