TLDR Survivin protein is crucial for hair growth and preventing cell death in hair follicles.
The study demonstrated that survivin, a protein involved in cell proliferation and apoptosis inhibition, was expressed in the proliferating keratinocytes of anagen hair follicles and decreased during the catagen phase. This expression was regulated by Wnt/β-catenin signaling. Survivin's dual role suggested its importance in the hair cycle's anagen and catagen phases. Using real-time PCR and immunohistochemistry on scalp skin from five individuals, the study found that inhibiting survivin transcription reduced hair growth and increased apoptosis in hair follicle cells.
277 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
236 citations,
July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
21 citations,
May 2016 in “Experimental and Therapeutic Medicine” MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
April 2016 in “Journal of Investigative Dermatology” Wnt ligands, produced by dermal papilla cells, are essential for adult hair growth and regeneration.
