Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

    Vladimir A. Botchkarev, Jiro Kishimoto
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    TLDR Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
    The document discussed the critical role of epithelial-mesenchymal interactions in hair follicle development and cycling, highlighting the distinct molecular signals that regulate each phase of the hair cycle. In the telogen phase, inhibitory signals keep the follicle quiescent, while in anagen, various growth stimulatory pathways are activated, essential for hair fiber formation. During catagen, the cessation of anagen-specific signals leads to epithelial apoptosis and a quiescent state in the dermal papilla. Proteoglycans like versican modulate these signaling exchanges. The study emphasized the need for further research to translate these findings into clinical treatments for hair growth disorders.
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