Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle

    Paul Edward Bowden, Sandra D. Hainey, Gillian A. Parker, David Jones, Drazen B. Zimonjic, Nicholas C. Popescu, Malcolm B. Hodgins
    Image of study
    TLDR Two specific hair keratin genes are active during hair growth and decline as hair transitions to rest.
    The study characterized and localized two type II hair-specific keratin genes, ghHb1 and ghHb6, on chromosome 12q13, and examined their expression patterns during the hair growth cycle. These genes, along with their type I partner ghHa1, were expressed in differentiating hair cortical cells during the anagen phase. In cultured follicles, ghHa1 expression declined after 6 days, while the basal epidermal keratin hK14 appeared in the regressing matrix. The transition from anagen to telogen involved downregulation of hair cortical specific keratins and the appearance of hK14 in the epithelial sac. The findings provided insights into the cyclical molecular changes in hair follicle growth, regression, and rest.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 6 months ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community The most depressing things about hair loss for me

      in Chat  24 upvotes 3 years ago
      The emotional impact of hair loss and the risks associated with common treatments such as finasteride, dutasteride, minoxidil, RU58841, and Fluridil. People discussed their personal experiences with these treatments, including potential side effects and lowered fertility. Hair transplants were also mentioned as a possible solution.

      community Is it possible that dutasteride won’t make you depressedd if finasteride did?

      in Chat  16 upvotes 6 months ago
      The conversation discusses whether dutasteride might cause less depression than finasteride for hair loss treatment, with some users suggesting it could due to different mechanisms of action or molecular size, while others express skepticism or share personal experiences with these medications.

    Related Research

    1 / 1 results