Sequence and Expression of Human Hair Keratin Genes

July 1994 in “ Journal of Dermatological Science ”

Paul E. Bowden, Sandra D. Hainey, Gillian A. Parker, Malcolm B. Hodgins

hair keratin genes low-sulphur hair keratins intermediate filament PCR genomic fragments cosmid clones type I keratin type II keratin in situ hybridization precortical cells hair follicle hair differentiation hair keratin

TLDR Human hair keratin genes are similar to mouse genes and are specifically expressed in hair follicles.

The study investigated the sequence and expression of human hair keratin genes, focusing on low-sulphur hair keratins, which are part of the intermediate filament (IF) multigene family. Researchers used PCR to amplify genomic fragments of human hair-specific keratin IF genes and isolated cosmid clones containing full-length genes. Sequencing revealed that type I and type II human hair-specific keratin clones showed significant homology to mouse sequences. In situ hybridization demonstrated specific expression in precortical cells of the hair follicle. The findings provided valuable molecular tools for studying hair differentiation.

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Research cited in this study

research Human Hair Keratins

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research Hair Follicle Differentiation: Expression, Structure, and Evolutionary Conservation of the Hair Type II Keratin Intermediate Filament Gene Family

research Structure and Site of Expression of a Murine Type II Hair Keratin

research Transient Expression of Mouse Hair Keratins in Transfected HeLa Cells: Interactions Between Hard and Soft Keratins

research Differential Expression of Type I Hair Keratins

research Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation

research Cloning And Characterization Of A Mouse Type I Hair Keratin cDNA

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues

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research A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression

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research The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins

research Hair Keratin: Composition, Structure and Biogenesis

research The Alpha-Fibrous Proteins of Epidermis

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