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    Glossary Type I Keratin

    Type I keratin is a fibrous protein that is a key structural component of hair, skin, and nails. It is classified as an acidic keratin and is primarily found in the hard tissues of the body, contributing to the strength and resilience of hair strands. In the context of hair loss, understanding type I keratin is relevant as it plays a crucial role in hair follicle health and integrity; any disruption in its production or structure can lead to weakened hair and increased susceptibility to hair loss. Distinguishing characteristics of type I keratin include its high tensile strength and its ability to form complex structures with other keratins, particularly type II keratins, to create the overall architecture of hair.

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    1. A group of type I keratin genes on human chromosome 17: characterization and expression. Molecular and Cellular Biology · 1988 · 141 citations
    2. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix Human Genetics · 1997 · 100 citations
    3. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    4. Type II Keratins Are Phosphorylated on a Unique Motif during Stress and Mitosis in Tissues and Cultured Cells Molecular Biology of the Cell · 2002 · 80 citations
    5. The human type I keratin gene family: Characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain Differentiation · 2004 · 70 citations
    6. Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007 · 70 citations
    7. Hair follicle differentiation: expression, structure and evolutionary conservation of the hair type II keratin intermediate filament gene family Development · 1992 · 65 citations
    8. Three cDNA sequences of mouse type I keratins. Cellular localization of the mRNAs in normal and hyperproliferative tissues. Journal of Biological Chemistry · 1987 · 57 citations
    9. A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13 Human Molecular Genetics · 1995 · 54 citations
    10. Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes Experimental Cell Research · 1995 · 52 citations
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