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Glossary Plasmacytoid Dendritic Cells

specialized immune cells producing large amounts of type I interferons

Plasmacytoid Dendritic Cells (pDCs) are a specialized type of immune cell known for their ability to produce large amounts of type I interferons in response to viral infections. They play a crucial role in the body's antiviral defense mechanisms and are also involved in linking the innate and adaptive immune responses.

Research

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research Plasmacytoid dendritic cells in alopecia areata: missing link?

45 citations , December 2014 in “Journal of the European Academy of Dermatology and Venereology”

This study found that plasmacytoid dendritic cells are central to the pathogenesis of alopecia areata, suggesting they may help differentiate it from trichotillomania and androgenetic alopecia.

research CD123 immunohistochemistry for plasmacytoid dendritic cells is useful in the diagnosis of scarring alopecia

20 citations , May 2016 in “Journal of Cutaneous Pathology”

This study suggests that the presence and arrangement of plasmacytoid dendritic cells can help distinguish chronic cutaneous lupus erythematosus from other types of scarring alopecia.

research Reply to ‘CD123 immunohistochemistry for plasmacytoid dendritic cells is useful in the diagnosis of scarring alopecia’: three PDC-related parameters are useful in differentiating lupus alopecia from LPP

4 citations , November 2016 in “Journal of Cutaneous Pathology”

This letter discusses three plasmacytoid dendritic cell-related parameters that may help differentiate lupus alopecia from lichen planopilaris, but it reports no new study results.

research Dendritic cell subsets in alopecia areata: focus on plasmacytoid dendritic cells and Langerhans cells in immune imbalance and therapeutic implications

July 2026 in “Expert Review of Clinical Immunology”

This article reviews the roles of dendritic cells in alopecia areata and highlights emerging precision therapies that target these cells, reporting no new experimental findings.

research Plasmacytoid dendritic cells as a key player in the initiation phase of alopecia areata-induced C3H/HeJ mouse

September 2016 in “Journal of Dermatological Science”

This study found that plasmacytoid dendritic cells may initiate alopecia areata in mice by overexpressing interferon-alpha.

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